We Tried the Most Popular Weight Loss Solutions—Here's What Actually Worked
By Dr. Sarah Chen, Medical Weight Loss Specialist
Last updated: February 3, 2025
Which GLP-1 weight loss programs actually work?
Henry Meds? Empower Pharmacy? Hims & Hers? NP2GO? TrimRx? Compounded semaglutide programs?
The list of medical weight loss programs out there never seems to end! But what's even more important is that all of them have different active approaches and service models.
Telehealth consultations? Direct pharmacy access? Virtual care platforms? Subscription models? How do you know which one to choose?
In my experience, some GLP-1 programs do work, but most don't provide the full support you need - and trying each and every one isn't cheap, is it?
Throughout my many years of experience as a Medical Weight Loss Specialist, it's been my job and life's passion to help my clients look and feel their best through sustainable, science-based approaches.
Fortunately, I've been lucky enough to try almost every type of compounded semaglutide program out there on myself and my clients.
Telehealth programs and direct pharmacy access do work, but there has always been one consistent winner I recommend to clients who want comprehensive medical support without the premium price tag.
Compounded semaglutide programs are proven to promote weight loss results, as studies indicate that GLP-1 hormone regulation is primarily effective when taken internally rather than through topical applications.
While direct pharmacy access has shown positive effects on medication availability, the telehealth approach through comprehensive medical support lacks substantial comparison for promoting long-term success without proper ongoing guidance.
My favorite weight loss solution? Full-service GLP-1 programs with 24/7 medical support!
Comprehensive medical intervention allows for better results and faster progress into the bloodstream, delivering essential hormone regulation directly to your appetite centers.
But with so many compounded semaglutide programs out there, it wasn't easy for me or my clients to find the programs that really provided complete care.
I've examined and tested many programs (so you don't have to!), and would love to share with you my top 5 that actually helped me and my clients lose weight sustainably.
#1 TrimRx Compounded Semaglutide
These weight loss specialists blow my mind! I came across them during my research endeavors, and I've been really impressed.
Whenever I would recommend TrimRx to my clients after their assessments - they'd always come back saying how their friends and family complimented them on how confident and healthy they looked.
TrimRx is prescription-based, medical-grade, and includes 24/7 doctor support. So you don't have to worry about being left alone once you start treatment.
It's weight loss superpower secret? A comprehensive medical support system combined with quality compounded semaglutide.
But don't let the word "comprehensive" fool you. Our bodies naturally produce appetite-regulating hormones (GLP-1), however, over time we produce less so finding a quality medical program with proper ongoing support is essential for sustainable results.
The reason that TrimRx was my number one pick was due to their product's rapid effectiveness and how quick it started to regulate my appetite and cravings.
It contains the same active ingredient as Ozempic and Wegovy, which is my recommended approach for taking GLP-1 internally for weight loss results, but with continuous medical guidance.
Due to its high-quality, prescription-grade ingredients and ongoing support, the weight loss effects came within just the first few weeks of daily use, whereas no other program I tested provided this level of comprehensive care.
#2 Henry Meds
Henry Meds may start at $147 for the first month, but if you're looking for affordable telehealth access to compounded semaglutide, this straightforward program could work for you.
Offering compounded semaglutide prescriptions through telehealth consultations with no insurance requirements. It plays a key role in providing accessible medication access and basic provider visits — while also including supplies and shipping in their monthly subscription.
It comes in at #2 instead of #1 because we saw good results with Henry Meds, but the ongoing medical support was much more limited compared to TrimRx. If you are looking for simple medication access without extensive ongoing guidance, Henry Meds is worth considering.
Check Out Henry Meds Program
#3 NP2GO Virtual Care
This virtual care platform offers accessibility and convenience through online consultations with licensed healthcare providers, but with limited comprehensive ongoing support.
This program provides access to compounded semaglutide through partnerships with trusted, state-licensed compounding pharmacies, known for its role in promoting personalized care and consistent quality.
Additionally, it incorporates virtual consultations that emphasize accessibility, which supports treatment convenience and consistent medication quality, contributing to overall program accessibility.
We felt this program, while it does work and provides decent personalized care, the depth of ongoing medical optimization felt more basic compared to some of the others, and hence why it takes my #3 spot.
Again, it contains proven medication and good virtual access, so I don't recommend it to those who need intensive medical guidance throughout their weight loss journey.
Check Out NP2GO Program
#4 Hims & Hers
This established telehealth company offers compounded semaglutide starting at $199 per month, but with limited personalized ongoing support.
This program provides access to compounded semaglutide through partnerships with FDA-registered compounding pharmacies, known for its role in promoting weight management accessibility.
Additionally, it incorporates basic weight management strategies and operates in both the U.S. and Europe, which supports treatment accessibility and convenience, contributing to overall program reach.
We felt this program, while it does work, the medical support felt more like customer service compared to some of the others, and hence why it takes my #4 spot. Again, it does contain proven medication. But I don't recommend it to those who need comprehensive medical guidance throughout their weight loss journey.
Check Out Hims & Hers Program
#5 Empower Pharmacy Direct
Empower Pharmacy is one of the nation's largest compounding pharmacies offering direct access to semaglutide with cyanocobalamin (Vitamin B12).
This established pharmacy operates both 503A and FDA-registered 503B facilities, ensuring regulatory compliance. It also provides various dosage strengths and sources ingredients from FDA-registered suppliers to help with medication quality and consistency.
While this pharmacy does provide quality compounded medications, I saw the need for separate medical consultations and guidance, which might be due to their pharmacy-focused approach rather than comprehensive medical program model. That's why Empower Pharmacy Direct takes my #5 spot.
Check Out Empower Pharmacy Options